Diagnostic Profile

expert-review-logoScope: Diagnostic Profile articles provide an overview of diagnostic products individually as they are approved and become available on the market.

Word limit: The word limit for Diagnostic Profiles is 5,000-7,000 words (not including abstract, key issues, figure and table legends, and references).

Every article must contain:

Title: Should be concise but informative, including the drug and therapeutic indication. Titles should not contain brand names

Authors’ names and addresses: Including address, academic qualifications and job titles of all authors, as well as telephone number, fax number and email address of the author for correspondence on a separate cover sheet as the peer reviewers will be blinded to the authors’ identity. Please note that only the address of the first author of the article will appear on Medline/PubMed, not necessarily the corresponding author.

Summary (maximum 150 words): The role of the summary is to draw in the interested casual browser. This should not be an abstract but should outline the article scope and briefly put it into context. No references should be cited in the summary.

Keywords: A brief list of keywords, in alphabetical order, is required to assist indexers in cross-referencing. The keywords will encompass the therapeutic area, mechanism(s) of action, key compounds etc.

Body of the article:

  • Introduction: Why is there a need for the test? How will it benefit treatment?
  • Market profile: Overview of the current market underlining the unmet needs of currently available therapies and highlighting which competitor compounds/classes of compounds are in the clinic/late development.
    How the test works: The technology basis, collection devices, sample types, ease of use, speed, and so on.
    Cost-effectiveness: Training, waste disposal, equipment required, and so on.
    Sensitivity and specificity
    Clinical profile: Phase I, II and III data
    Alternative tests: A standalone box, summarizing competing tests in the field

Expert commentary: 500-1000 words (included in overall word count).
To distinguish the articles published in the Expert Review series, authors must provide an additional section entitled ‘Expert commentary’. This section affords authors the opportunity to provide their interpretation of the data presented in the article and discuss the developments that are likely to be important in the future, and the avenues of research likely to become exciting as further studies yield more detailed results. The intention is to go beyond a conclusion and should not simply summarise the paper. Authors should answer the following:

  • What are the key weaknesses in clinical management so far?
  • What potential does further research hold? What is the ultimate goal in this field?
  • What research or knowledge is needed to achieve this goal and what is the biggest challenge in this goal being achieved?
  • Is there any particular area of the research you are finding of interest at present?

Please note that ‘opinions’ are encouraged in the Expert commentary section, and, as such, referees are asked to keep this in mind when peer reviewing the manuscript.

Five-year view: Authors are challenged to include a speculative viewpoint on how the field will have evolved five years from the point at which the review was written.

Key issues: An executive summary of the authors’ main points (bulleted) is very useful for time-constrained readers requiring a rapidly accessible overview.

References: A maximum of 100 references is suggested. Ensure that all key work relevant to the topic under discussion is cited in the text and listed in the bibliography. Reference to unpublished data should be kept to a minimum and authors must obtain a signed letter of permission from cited persons to use unpublished results or personal communications in the manuscript.

Reference annotations: Important references should be highlighted with a one/two star system and brief annotations should be given (see the journal’s Instructions for Authors page for examples and for a more detailed description of our referencing style).

Figures and Tables: Up to 5 figures and 5 tables are permitted. For further information on tables and figures, please see our formatting guide.

Financial disclosure and acknowledgements