Authors should include the following sections in the main body of their manuscript:
Introduction: The paper under discussion must be introduced and referenced as Reference . The scientific and/or commercial rationale behind the paper is presented, giving some perspective on the information disclosed, placing it in context with previous research in the same area and indicating the relative importance of this new work. Authors may highlight other contemporary papers, which have relevance to the main paper; these may support or conflict the results. It is essential that a critical stand is taken when writing.
Summary of methods and results: Briefly summarise the methods the authors used and the main results obtained. Quote the number of patients, criteria for selection, doses used, route of administration, adverse effects and so on as appropriate.
Discussion: This should be the main draw of the manuscript. Comment on the extent and quality of the study, and how elegantly it was performed. It should contain your opinion of the developments; is the paper going to affect future research? Is this method/treatment likely to become standard practice? If not, indicate why you think the paper is nevertheless of interest. Give your opinion on the developments that you have discussed in the article. Comparative assessment is encouraged. When evaluating the paper, the authors should place emphasis on the therapeutic significance if possible and possibly compare this to other therapies in the same area.
Conclusion: A short concluding paragraph.